Siren, L.L.C portfolio

What changed this quarter

78 positions with a change (17 new, 32 added to, 21 trimmed, 8 sold); also, 4 entered through an IPO, 1 exited through an acquisition or merger, 3 entered through a spin-off. 9 are listed here: those of 0.5 points of the portfolio or more (up to 12).

• Abivax+1.6 ppof portfolioNew
  — → 1.6%
• Scholar Rock Holding−12%fewer sharesReduced
  14.8% → 10.7%
• Relay Therapeutics+1.4 ppof portfolioNew
  — → 1.4%
• Enliven Therapeutics+138%more sharesIncreased
  0.8% → 1.8%
• Edgewise Therapeutics−28%fewer sharesReduced
  3.9% → 2.6%
• Rhythm Pharmaceuticals+57%more sharesIncreased
  1.7% → 2.6%
• Revolution Medicines−19%fewer sharesReduced
  3.0% → 3.4%
• Capital One Financial+0.7 ppof portfolioNew
  — → 0.7%
• Kymera Therapeutics−7.9%fewer sharesReduced
  7.4% → 6.8%

The figure on the right: for positions added to or trimmed, the change in the number of shares (%); for new and sold ones, the points of the portfolio moved (pp). Below, the portfolio weight before → after. Traded weight?: what it bought or sold, excluding price effects.

Top holdings

• Scholar Rock HoldingSRRK10.7%
• Kymera TherapeuticsKYMR6.8%
• ErascaERAS4.2%
• VeradermicsMANE4.1%
• Tango TherapeuticsTNGX3.9%
• Revolution MedicinesRVMD3.4%
• Bicara TherapeuticsBCAX3.4%
• Arrowhead PharmaceuticalsARWR2.8%
• Beone MedicinesONC2.7%
• Edgewise TherapeuticsEWTX2.6%
• Rhythm PharmaceuticalsRYTM2.6%
• Lexicon PharmaceuticalsLXRX2.2%
• Enliven TherapeuticsELVN1.8%
• Spyre TherapeuticsSYRE1.7%
• Parabilis MedicinesPBLS1.7%
• Xenon PharmaceuticalsXENE1.6%
• Solid BiosciencesSLDB1.6%
• AbivaxABVX1.6%
• Hemab Therapeutics HoldingsCOAG1.6%
• Arcus BiosciencesRCUS1.5%
• Cogent BiosciencesCOGT1.5%
• Relay TherapeuticsRLAY1.4%
• Taysha Gene TherapiesTSHA1.4%
• Definium TherapeuticsDFTX1.4%
• Stoke TherapeuticsSTOK1.3%
• Disc MedicineIRON1.3%
• CytokineticsCYTK1.3%
• SepternaSEPN1.3%
• Olema PharmaceuticalsOLMA1.2%
• Crinetics PharmaceuticalsCRNX1.1%
• Kailera TherapeuticsKLRA1.0%
• Dyne TherapeuticsDYN1.0%
• Structure TherapeuticsGPCR1.0%
• Taboola.comTBLA0.9%
• Palvella TherapeuticsPVLA0.8%
• Silence TherapeuticsSLN0.7%
• Denali TherapeuticsDNLI0.7%
• Remitly GlobalRELY0.7%
• Cullinan TherapeuticsCGEM0.7%
• Capital One FinancialCOF0.7%
• Trevi TherapeuticsTRVI0.7%
• ORIC PharmaceuticalsORIC0.7%
• AlphabetGOOGL0.7%
• DBV TechnologiesDBVT0.6%
• AbsciABSI0.6%
• Sionna TherapeuticsSION0.5%
• Rapport TherapeuticsRAPP0.5%
• Amylyx PharmaceuticalsAMLX0.5%
• AnnexonANNX0.5%
• Monopar TherapeuticsMNPR0.5%
• Oruka TherapeuticsORKA0.5%
• Seaport TherapeuticsSPTX0.5%
• Damora Therapeutics0.5%
• Tyra BiosciencesTYRA0.5%
• Zura BioZURA0.4%
• Taiwan Semiconductor ManufacturingTSM0.4%
• NVIDIANVDA0.4%
• RezoluteRZLT0.4%
• MapLight TherapeuticsMPLT0.3%
• Neumora TherapeuticsNMRA0.3%
• Nebius GroupNBIS0.3%
• MicrosoftMSFT0.3%
• CytomX TherapeuticsCTMX0.3%
• Generate BiomedicinesGENB0.3%
• Inhibikase TherapeuticsIKT0.2%
• AdageneADAG0.2%
• enGene TherapeuticsENGN0.2%
• Whitehawk TherapeuticsWHWK0.2%
• DatadogDDOG0.2%
• ServiceNowNOW0.2%
• BroadcomAVGO0.2%
• IonQIONQ0.2%
• JFrogFROG0.2%
• Oculis HoldingOCS0.2%
• IRENIREN0.2%
• Amazon.comAMZN0.2%
• CrowdStrike HoldingsCRWD0.2%
• Design TherapeuticsDSGN0.2%
• PDD HoldingsPDD0.1%
• Satellos BioscienceMSLE0.1%
• DynatraceDT0.1%
• Tenax TherapeuticsTENX0.1%
• vTv TherapeuticsVTVT0.1%
• Eloxx PharmaceuticalsELOX0.1%
• AgomAb TherapeuticsAGMB0.1%
• Alibaba Group HoldingBABA0.1%
• Korro BioKRRO0.1%
• Cellebrite DICLBT0.1%
• InvivydIVVD0.1%
• OusterOUST0.1%
• Palisade BioPALI0.1%
• AEVA TechnologiesAEVA0.1%
• SEERSEER0.1%
• NovaBridge BiosciencesNBP0.1%
• GitlabGTLB0.1%
• Odyssey TherapeuticsODTX0.1%
• Foghorn TherapeuticsFHTX0.1%
• AgenusAGEN0.1%
• monday.comMNDY0.1%
• ZoetisZTS0.1%